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Materials and Methods: From January to December65 prenatal cases with fetal brain malformations 10 with minor extracerebral anomalies were investigated by targeted Next Generation Sequencing of the coding regions of genes.

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Multiple renal cortical cysts and bilateral upper and lower limb post-axial polydactyly were observed. This percentage ificantly increases with advancing age in women and in cases of abnormalities of sperm in men.

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Aten1, Trio-based whole exome sequencing should be considered in cases with negative MGPA to further improve the detection rate. Andreassen: None. Tosumoglu1, T. Pregnant or breast-feeding, S.

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